QuickView for oxysterol binding protein;jsessionid=C29336D5516EF536524184833265134C;jsessionid=21436D61F7EBA947A5D9C39A438BDB4E (gene)

Gene Symbol:

Osbp2 Mus musculus

Full name:

oxysterol binding protein 2

Synonyms:

1700095P05Rik, C630001G20Rik, Gm244, ORP-4, OSBPL1, oxysterol-binding protein 2

Genomic Location:

Chr 11: 3603734-3763906

Description:

The protein encoded by this gene belongs to the oxysterol-binding protein-related family of proteins, which are defined by a C-terminal sterol domain with a highly conserved EQVSHHPP motif. Oxysterols are oxygenated derivatives of cholesterol that are involved in mechanisms that include apoptosis, cholesterol homeostasis, lipid trafficking and cell...

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The protein encoded by this gene belongs to the oxysterol-binding protein-related family of proteins, which are defined by a C-terminal sterol domain with a highly conserved EQVSHHPP motif. Oxysterols are oxygenated derivatives of cholesterol that are involved in mechanisms that include apoptosis, cholesterol homeostasis, lipid trafficking and cell differentiation. This protein is selectively expressed at high levels in the brain and testis. Within the testis, the mRNA is localized to postmeiotic germ cells, including spermatids and spermatozoa, but is not detectable in somatic cells. Mice homozygous mutant for a targeted deletion in this gene do not exhibit overt developmental phenotypes but are male sterile. Females display normal fertility. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

EGR_Q6 ,  SP1_Q2_01 ,  AGGAAGC_MIR5163P ,  TGCCTTA_MIR124A ,  CATTGTYY_SOX9_B1

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-31 ,  Predicted Gene Targets for miR-410

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